Artichoke Spinach Grilled Cheese

Featured in: Weeknight Dinners

Transform your sandwich game with this artichoke spinach grilled cheese, combining the beloved flavors of spinach-artichoke dip in a warm, melted masterpiece. Layer a creamy blend of cream cheese, mozzarella, Monterey Jack, and Parmesan with fresh spinach and artichoke hearts between buttered sourdough slices, then griddle until golden and gooey.

Ready in just 25 minutes, this vegetarian main yields four satisfying sandwiches perfect for lunch or a light dinner. Serve alongside tomato soup or a crisp salad for the ultimate comfort meal.

Updated on Tue, 20 Jan 2026 16:26:00 GMT
Golden brown sourdough slices reveal a creamy spinach-artichoke grilled cheese, melted and steaming on a plate. Pin It
Golden brown sourdough slices reveal a creamy spinach-artichoke grilled cheese, melted and steaming on a plate. | urbanspatula.com

The idea came to me during a particularly rainy Tuesday when I was craving something comforting but had half a jar of artichokes staring back from the fridge. Why not combine the best parts of spinach artichoke dip with the nostalgia of a grilled cheese? That first sandwich, with its golden crust giving way to that creamy, cheesy center, was absolutely transformative. Now whenever gray skies roll in, this is exactly what my kitchen starts smelling like.

I served these at a casual dinner with friends last winter, and honest to goodness, the conversation stopped after the first bite. Someone actually asked if I could make them again the very next week. Theres something about the familiar comfort of grilled cheese meeting that sophisticated spinach artichoke flavor profile that makes people sit up and pay attention.

Ingredients

  • 1 cup fresh spinach, chopped: Fresh gives you better texture, but frozen works in a pinch just thaw and squeeze out all that excess water so your sandwich doesnt get soggy
  • 1 cup artichoke hearts, drained and chopped: The marinated kind from a jar adds extra flavor, but canned works perfectly fine too
  • 4 oz cream cheese, softened: Let this sit out for 20 minutes before mixing, otherwise youll get lumps in your filling
  • ½ cup shredded mozzarella: This is your melt factor cheese that creates those gorgeous cheese pulls
  • ½ cup Monterey Jack or Swiss: Either brings great flavor, Swiss adds a slightly nuttier note while Jack is milder
  • ¼ cup grated Parmesan: Adds that salty, umami punch that makes the filling taste restaurant quality
  • 2 tbsp unsalted butter, softened: Room temperature spreads so much more evenly than cold butter on the bread
  • 8 slices sourdough bread: The tangy sourdough perfectly balances all that creamy cheese inside
  • 1 small garlic clove, minced: Fresh garlic makes such a difference here, garlic powder just doesnt quite hit the same notes
  • ¼ tsp black pepper: Freshly cracked gives you those little bursts of heat throughout
  • ⅛ tsp crushed red pepper flakes: Totally optional, but I love the subtle warmth it sneaks in
  • Pinch of salt: Just enough to bring all the flavors together without overwhelming

Instructions

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Mix up your filling:
In a mixing bowl, combine all those cheeses with spinach, artichokes, garlic, and seasonings until everything is evenly distributed and creamy
Assemble the sandwiches:
Spread that gorgeous filling generously onto four slices of bread, then top with the remaining slices to close them up
Butter the bread:
Spread softened butter on the outside of each sandwich, getting right to the edges so every bite gets perfectly golden
Grill to perfection:
Cook in a heated skillet over medium heat for about 4 minutes per side, pressing gently, until golden brown and the cheese is melting out the sides just a little
Rest and serve:
Let them sit for just one minute before slicing diagonally and serving while still warm and gooey
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A close-up shows crisp crust and melted cheese oozing from this spinach-artichoke grilled cheese. Pin It
A close-up shows crisp crust and melted cheese oozing from this spinach-artichoke grilled cheese. | urbanspatula.com

These have become my go to when I need to feed a crowd without spending hours in the kitchen. Theres something universally comforting about a grilled cheese, but elevate it with this filling and suddenly it feels like something special enough for company.

Perfect Soup Pairings

A simple tomato soup is the classic companion, but I also love serving these alongside a light brothy soup or even just some roasted tomatoes when you want something fresher. The acidity cuts beautifully through all that rich cheese.

Bread Wisdom

Sourdough is my absolute favorite here because it holds up well to all that moisture and develops such a beautiful crust. But honestly, any sturdy bread works, just avoid anything too soft or thinly sliced that might fall apart under the weight of the filling.

Make Ahead Magic

The filling can be made up to two days ahead and stored in the refrigerator, which makes these perfect for busy weeknights or when youre prepping for a party. Just bring it to room temperature for about 15 minutes before spreading so it spreads evenly.

  • If making ahead, sprinkle a little extra cheese right before grilling to revive the flavors
  • These reheat surprisingly well in a 350 degree oven for about 10 minutes if you somehow have leftovers
  • The filling is also fantastic stuffed inside a chicken breast or used as a dip for crackers
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A plate with tomato soup and a halved spinach-artichoke grilled cheese, perfect for a cozy meal. Pin It
A plate with tomato soup and a halved spinach-artichoke grilled cheese, perfect for a cozy meal. | urbanspatula.com

Hope these bring as much cozy comfort to your kitchen as they have to mine. Happy cooking!

Questions & Answers

Can I prepare the filling ahead of time?

Yes, you can prepare the artichoke-spinach mixture up to 2 days in advance. Store it in an airtight container in the refrigerator, then assemble and cook your sandwiches whenever ready.

What bread alternatives work well for this sandwich?

While sourdough provides excellent flavor and structure, you can substitute with whole wheat bread for added fiber, brioche for richness, or gluten-free bread to accommodate dietary needs. Adjust cooking time slightly based on bread thickness.

How do I prevent the filling from leaking out?

Spread the filling evenly and avoid overstuffing—aim for a thin, consistent layer on each slice. Press gently while cooking to help the cheese bind ingredients together. Rest sandwiches briefly after cooking to allow cheese to set.

Can I add other ingredients to the filling?

Absolutely. Sun-dried tomatoes, chopped scallions, roasted red peppers, or fresh basil complement the spinach-artichoke base beautifully. Add extra ingredients sparingly to maintain even cooking and prevent the sandwich from becoming too thick.

What's the best pan for achieving crispy, golden bread?

A cast iron skillet or flat griddle distributes heat evenly and creates excellent browning. For nonstick options, use a well-seasoned nonstick skillet over medium heat. Avoid high temperatures, which can brown bread too quickly before cheese melts.

Is this sandwich suitable for freezing?

The filling freezes well separately for up to 3 months. However, assembled and cooked sandwiches don't freeze successfully, as the bread becomes soggy upon thawing. Prepare filling in batches and cook fresh as needed.

Artichoke Spinach Grilled Cheese

Decadent grilled cheese with creamy spinach-artichoke dip filling, melted to perfection on golden sourdough bread.

Prep Time
15 minutes
Cook Time
10 minutes
Overall Time
25 minutes
Created by Carter Phillips


Skill Level Easy

Cuisine American

Portions 4 Serving Size

Diet Preferences Meat-Free

What You’ll Need

Vegetables

01 1 cup fresh spinach, chopped (or 1/2 cup frozen, thawed and drained)
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes (optional)
04 Pinch of salt

How-To Steps

Step 01

Prepare the filling: In a mixing bowl, combine softened cream cheese, mozzarella, Monterey Jack or Swiss cheese, Parmesan, chopped spinach, drained artichoke hearts, minced garlic, black pepper, red pepper flakes, and salt. Mix until well blended.

Step 02

Assemble sandwiches: Lay out the sourdough slices. Spread the artichoke-spinach mixture evenly onto 4 slices. Top with remaining bread slices to form complete sandwiches.

Step 03

Butter exterior: Lightly spread softened butter on the outside of each sandwich on both sides.

Step 04

Cook sandwiches: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and serve: Remove sandwiches from skillet and let rest for 1 minute. Slice diagonally and serve warm.

Tools You’ll Need

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy Warnings

Review every ingredient for allergens and ask a professional if you’re unsure.
  • Contains dairy (cheese, butter) and wheat (bread)
  • May contain soy depending on bread and cheese brand selections
  • Check manufacturer labels for potential cross-contamination with allergens

Nutrition Info (for each serving)

These nutrition details are for reference and don’t replace medical guidance.
  • Energy: 410
  • Fats: 23 g
  • Carbohydrates: 38 g
  • Proteins: 15 g